As agreed with Blaz, tune for fly, 30+ might not be necessary but you're going to need at least 12 to survive in the back. (More if you want to rush in the front lines with it.)
Misside AMs aren't completely useless but they don't exactly add enough firepower for them to be useful on Destructor CN (TGH reductions cause it to be negligible)
2x Large zookas aren't a bad idea but the stat reductions really hurt him, mobility is essential unless you're confident that you can destroy/stun the other bot BEFORE they reach you. (And besides Air bots sadly, Destructors aren't too good at doing that...)
Alpha-ing with Destructors aren't impossible but they certainly don't make good breakers, if you want a good breaker either go for something with dual (custom) shotguns or dual 8/delta vulcans, they should work much more efficiently than spamming missile/zookas. (The TGH damage reduction pretty much cause every one of your zookas after 3 shots do deal 1 damage. Shotguns and Vulcans work well because their attack rate still allows them to spray enough bullets to deal significant numbers)
Here's my own personal build of it:
(Please note that I have yet to tune anything AND I'm trying to make it UC friendly, strangely enough, it also matches Shinn's recommendations... OAO!)
If you're good with aiming then this should be able to knock down most air units before they have a chance to strike, just make sure you have a good amount of elevation.
Skill is required to play this build, you're usually going to have to allow your zookas to lead your target. (which in other words mean; you're probably going to have to shoot at where they're going to be travelling to rather than directly at them)